Senior Scientist, NHP Study Lead / Analyst

Stylus Medicine

Salary: $160k - $175k
Experience: 4+ yrs
Location: Cambridge, Massachusetts, United States
Job type: Full-time

Required skills

flow cytometry
ddPCR
LNP
CART
PBMC isolation
immunology assays
lab notebook
data analysis

About the role

About Stylus Medicine:

Stylus Medicine is developing transformative in vivo genetic medicines to unlock cures. Stylus combines engineered recombinases with non-viral delivery to specifically encode therapeutics. The company’s approach is versatile and modular, with potential therapeutic application across oncology, autoimmune, genetic diseases, and beyond.

About the Role:

Stylus Medicine is seeking a highly motivated and collaborative Senior Scientist to join our in vivo Pharmacology team. This role will be responsible for leading NHP studies, including working closely with CROs to manage studies, contribute to protocol writing and design, obtain, quality control, analyze and interpret data, lead investigative technical troubleshooting, ensure consistency in execution across studies, and create detailed and thorough study summaries. Reporting to the Director of in vivo Pharmacology and working closely with cross-functional teams, this is a unique opportunity to contribute to foundational development in a fast-paced, cutting-edge biotech environment and advance the development of transformative in vivo genetic medicines.

Key Responsibilities & Accountabilities:

Design NHP study protocols and lead CRO communication
Analyze, interpret, and communicate NHP study data, including flow cytometry analysis, cytokine analysis and other ex vivo readouts, to inform project direction and decision-making
Evaluate data for consistency and follow-up as needed, working closely with CROs to optimize study protocols
Investigate and interpret biological findings from NHP studies
Manage NHP study test article generation and transfer in collaboration with internal cross-functional teams
Conduct experiments to optimize protocols for CRO transfer or investigate biological findings
Generate and manage study documentation, including protocols and study reports
Effectively communicate findings to internal teams.
Maintain detailed and accurate laboratory records in compliance with data integrity and documentation standards
Limited travel may be required

Qualifications & Skills:

PhD in Pharmacology, Immunology, Immuno-oncology, or a related field with 4-6 years of relevant industry or academic experience, or a Master's degree with 8+ years of experience
Demonstrated experience with ex vivo analytical techniques, such as flow cytometry, cytokine analysis, and ddPCR
Demonstrated ability to design, execute, interpret, and troubleshoot immunology-related in vivo studies and to coordinate the activities of multiple study contributors
Experience coordinating with animal vendors, CROs or external collaborators
Prior experience with NHP studies is preferred
Experience in designing experiments to address PK/PD/biodistribution/tox relationships is a plus
Experience with LNP or CART delivery technologies and genetic medicine platforms is a plus
Experience with T cell or PBMC isolation and handling from peripheral blood, engineering, and downstream immunological or molecular assays
Demonstrated ability to work independently in a laboratory setting, learn new techniques, multitask effectively, and maintain meticulous records
Demonstrated proficiency in documenting and maintaining an organized lab notebook, lab inventory, and experimental results
Excellent organizational and communication skills, with a team-first mindset and the ability to convey technical information
Analytical thinker with the ability to distill complex data into clear, actionable insights

Pay Range: $160,000 - $175,000

About Stylus Medicine

Develops in vivo genetic medicines with recombinases and nanoparticles.

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