Mithros Chemicals PVT LTD
Website:
mithros.com
Job details:
Position Overview:
Mithros is seeking a highly motivated and skilled Process Chemist with strong expertise in Flow Chemistry / Continuous Manufacturing to join our Process Research & Development team for newly Build Facilty. The successful candidate will lead the development, optimization and scale-up of chemical processes using continuous-flow and flow-based technologies, while also supporting conventional batch process development. This role is ideal for a chemist who enjoys solving challenging process problems and translating laboratory chemistry into safe, robust, scalable and commercially viable processes.
Key Responsibilities:
Flow Chemistry & Process Development
- Design, develop and optimize chemical reactions using continuous-flow technology.
- Translate batch reactions into continuous-flow processes where technically and commercially advantageous.
- Optimize reaction parameters including residence time, temperature, pressure, flow rate, concentration, stoichiometry and mixing.
- Evaluate different reactor technologies and flow configurations.
Process Optimization & Scale-Up
- Develop robust and scalable processes from milligram/gram scale through kilogram and pilot scale.
- Establish process understanding using Design of Experiments (DoE) and systematic parameter optimization.
- Improve yield, selectivity, productivity, impurity profile and overall process economics.
- Develop continuous processes with improved safety, productivity and reduced solvent/raw-material consumption.
- Identify opportunities for process intensification and automation.
Process Safety
- Assess reaction hazards and identify opportunities where flow chemistry can improve process safety.
- Work with calorimetry and reaction-safety data to define safe operating windows.
- Develop processes for hazardous reagents and intermediates using appropriate containment and engineering controls.
- Contribute to HAZOP/process safety assessments for flow systems.
- Equipment & Technology Development
- Select and evaluate flow reactors, pumps, mixers, heat exchangers, back-pressure regulators and related equipment.
- Develop and commission laboratory and pilot-scale flow chemistry equipment.
- Troubleshoot flow systems including Blockages, Precipitation, Fouling, Pressure fluctuations, Pumping/mixing problems, Heat-transfer limitations, Gas–liquid mass-transfer issues
- Develop integrated reaction–work-up systems where appropriate.
Downstream Processing
- Develop compatible continuous or semi-continuous downstream operations, including Quenching, Liquid–liquid extraction, Crystallization, Precipitation, Filtration, Solvent exchange, Distillation
- Evaluate integration of reaction and purification steps into continuous processes.
Scale-Up & Technology Transfer
- Translate laboratory flow processes to pilot and production scale.
- Establish scale-up strategies based on residence time, mixing, heat transfer and mass-transfer characteristics rather than simple volume scaling.
- Prepare process descriptions, experimental protocols, batch/flow records and technology-transfer packages.
- Support manufacturing teams and external partners during process implementation.
Client & Project Responsibilities
- Lead technical discussions with clients on process chemistry and flow technology.
- Prepare technical proposals, project plans, timelines and resource estimates.
- Present process-development results to clients and internal management.
- Identify opportunities where flow chemistry can provide a significant advantage in cost, safety, quality, speed or scalability.
Required Qualifications
- PhD in Organic Chemistry or Process Chemistry.
- Typically, 5–8+ years of industrial experience in process chemistry, process development or continuous-flow chemistry.
- Strong hands-on experience with flow chemistry / continuous processing.
- Demonstrated experience in taking chemical processes from laboratory development toward larger scale.
- Strong understanding of reaction kinetics, mass transfer, heat transfer and process engineering principles.
- Experience with process analytical techniques and analytical characterization.
- Good knowledge of organic chemistry and synthetic methodology.
- Strong problem-solving and experimental-design capabilities.
- Ability to work independently and lead technical projects.
Highly Desirable Experience
Experience in one or more of the following would be a strong advantage:
- Continuous-flow scale-up
- Microreactors and tubular reactors
- Gas–liquid flow chemistry
- Continuous hydrogenation
- Continuous crystallization
- Inline/online analytical technologies
- PAT and process monitoring
- Automated flow platforms
- DoE/QbD approaches
- Process safety and reaction calorimetry
Why Join Mithros?
This position offers an exciting opportunity to work at the interface of synthetic chemistry, process engineering, and advanced manufacturing technologies. The successful candidate will have the opportunity to build and develop flow-chemistry capabilities at Mithros, work on challenging chemistry projects for international clients, and contribute to the development of next-generation chemical processes that are safer, faster, more efficient, and cost-effective. The role also provides opportunities for advanced technical training and knowledge development in flow chemistry at Taros Chemical in Germany, the parent organization of Mithros. This international exposure will enable the successful candidate to further strengthen their expertise in flow chemistry, process intensification, scale-up, and continuous manufacturing technologies.
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