Website:
aventaa.com
Job details:
Location: Ahmedabad, Gujarat
Experience: 2–5 Years
Department: R&D – Peptide Chemistry
Employment Type: Full-Time
About the Role
We are looking for a motivated and technically skilled Scientist – Peptide Chemistry with 2–5 years of hands-on experience in peptide synthesis, with strong practical knowledge of peptide chemistry, SPPS, cyclic peptide synthesis, purification, and characterization.
Key Responsibilities
* Perform SPPS and solution-phase peptide synthesis as required.
* Execute linear and cyclic peptide synthesis using appropriate strategies.
* Plan synthesis routes based on sequence, complexity, and desired modifications.
* Handle coupling, deprotection, cleavage, and related operations.
* Develop and optimize cyclic peptide synthesis and cyclization strategies.
* Troubleshoot incomplete coupling, deletion sequences, aggregation, and low yields.
* Purify peptides using preparative/reverse-phase HPLC and other suitable techniques.
* Analyze peptides using analytical HPLC/UPLC.
* Characterize peptides using LC-MS/Mass Spectrometry and relevant analytical techniques.
* Interpret analytical data and confirm peptide identity, purity, and molecular weight.
* Maintain laboratory records, experimental data, and synthesis documentation.
* Prepare technical reports and communicate project progress to the R&D team.
* Follow laboratory safety, quality, and documentation procedures.
* Collaborate with analytical, process development, and other R&D teams.
Required Qualifications
* M.Sc./M.Tech./Ph.D. in Organic Chemistry, Medicinal Chemistry, Pharmaceutical Chemistry, Chemistry, or related discipline.
* 2–5 years of relevant hands-on experience in peptide chemistry/peptide synthesis.
* Strong practical experience in SPPS and good understanding of peptide structure, chemistry, and synthesis strategies.
* Hands-on experience with cyclic peptide synthesis/cyclization.
* Practical experience in peptide purification using preparative HPLC.
* Experience with analytical HPLC/UPLC and LC-MS/MS or Mass Spectrometry.
* Ability to interpret analytical data and troubleshoot peptide synthesis and purification challenges.
* Good laboratory practices and strong attention to experimental details.
Preferred Skills
* Experience with Fmoc-based peptide synthesis.
* Knowledge of peptide coupling reagents and protecting-group chemistry.
* Experience with complex, long, or difficult peptide sequences.
* Knowledge of peptide modifications such as N-terminal/C-terminal modifications, labeling, stapling, lipidation, or non-natural amino acids.
* Experience with automated peptide synthesizers.
* Good problem-solving and troubleshooting skills.
* Ability to work independently and within a multidisciplinary R&D team.
Key Competencies
Peptide Synthesis | SPPS | Cyclic Peptides | Peptide Chemistry | HPLC Purification | RP-HPLC | Analytical HPLC/UPLC | LC-MS | Peptide Characterization | Organic Chemistry | Troubleshooting
What We Offer
* Opportunity to work on challenging and innovative peptide chemistry projects.
* Exposure to advanced peptide synthesis, purification, and characterization techniques.
* Collaborative and research-oriented work environment.
* Opportunities for technical and professional growth.
Click on Apply to know more.
