ManoTri Pharma Pvt Ltd
Website:
manotripharma.com
Job details:
Role Summary
We are seeking an accomplished Lead Chemist – Oligonucleotide Chemistry to establish and lead an oligonucleotide chemistry laboratory focused on both generic and novel oligonucleotide therapeutics. This role will be responsible for laboratory setup, method development, execution of synthesis, process optimization, and scientific leadership from early research through clinical and commercial readiness.
Key Responsibilities
Laboratory Setup & Infrastructure
Lead end-to-end setup of the oligonucleotide chemistry laboratory, including equipment selection, installation, qualification, and operational readiness
Establish laboratory workflows for solid-phase oligonucleotide synthesis, purification, and characterization
Develop SOPs and ensure compliance with GLP/GMP-ready practices and EHS standards
Oligonucleotide Synthesis & Development
Design and execute synthesis of DNA, RNA, siRNA, antisense oligonucleotides (ASOs), and modified oligonucleotides
Develop, optimize, and troubleshoot solid-phase synthesis processes using phosphoramidite chemistry
Lead development of novel oligonucleotide chemistries, backbone modifications, and conjugation strategies
Support both generic product development and novel therapeutic pipelines
Purification & Characterization
Develop and oversee purification methods including HPLC, ion-exchange chromatography, and desalting
Ensure comprehensive analytical characterization using HPLC, LC–MS, UV, CE, and other relevant techniques
Define specifications and acceptance criteria for intermediates and final drug substances
Process Optimization & Scale-Up
Lead process development and scale-up activities from laboratory to pilot scale
Identify opportunities to improve yield, purity, robustness, and cost efficiency
Support technology transfer to manufacturing facilities or external CDMOs
Scientific & Team Leadership
Build, mentor, and manage a team of chemists and research associates
Review experimental design, data integrity, and technical documentation
Provide scientific direction and decision-making for oligonucleotide programs
Cross-Functional Collaboration & Regulatory Support
Collaborate with analytical, formulation, biology, QA, and regulatory teams
Support preparation of CMC documentation for regulatory submissions (IND, DMF, ANDA, or equivalent)
Contribute to intellectual property generation, patent drafting, and scientific publications
Required Qualifications
Education
PhD or Master’s degree in Chemistry, Organic Chemistry, Medicinal Chemistry, or a related discipline
Experience
8–12+ years of hands-on experience in oligonucleotide chemistry
Strong industrial or advanced academic experience in solid-phase oligonucleotide synthesis
Demonstrated experience in laboratory setup, process development, and scale-up
Experience working on generic oligonucleotides and/or novel therapeutic oligos
Technical Expertise
Deep knowledge of phosphoramidite chemistry
Experience with oligonucleotide modifications (e.g., phosphorothioates, 2′-OMe, LNA, conjugates)
Proficiency in oligonucleotide purification and analytical characterization
Understanding of GMP expectations and CMC requirements
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