Description
We are seeking a highly skilled and motivated Senior Scientist specializing with Biochemistry/Chemistry background to join B2S Critical Reagents Team Umbrella. The ideal candidate will play a key role in diligent design, generation, and characterization of critical reagents directly to the advancement of large molecule bioanalytical pipelines.
Position Summary:
The Senior Scientist I – Critical Reagents is responsible for the generation, characterization, and lifecycle management of custom critical reagents to support the development of robust, regulated bioanalytical assays for large-molecule biotherapeutics. Critical reagents include well-characterized polyclonal and monoclonal antibodies, recombinant proteins, conjugated proteins and peptides, gene therapy vectors, oligonucleotides, and critical reagent kits.
This position offers an exciting opportunity to lead and collaborate within a multidisciplinary scientific environment, contributing to innovation, assay robustness, and scientific excellence across the development lifecycle of large-molecule biotherapeutics.
Key Responsibilities.
- Serves as a Scientist/Principal Scientist for clients’ projects.
- Performs a variety of protein conjugation chemistry, protein purification activities and downstream biochemical/bioanalytical and biophysical characterization methodologies.
- Able to design, execute, trouble shoot experiments associated with critical reagents generation and /or characterization with minimum supervision.
- Compiles scientific data (including analysis and technical writing) and able to present data in an intelligible format suitable for a professional audience.
- Able to train junior level scientists.
- Reports and treats data with prominent level of integrity and ethics.
- Complies with application able regulations (GXP); maintains proper records in accordance with standard operating procedures (SOPs) and policies; independently designs and performs scientific experiments with a pre-defined goal including developing new methodologies, protocols, and/or test procedures that contribute to core group research goals and reflect expert knowledge.
- Independently apply basic scientific principles, performs literature searches, attends scientific meetings, and keeps up to date on literature in the biotherapeutic bioanalysis field.
- Maintains laboratory equipment, as needed.
- Other duties as assigned
Competencies:
- Quality and Quantity – Demonstrates accuracy and thoroughness; Looks for ways to improve and promote quality; Applies feedback to improve performance; Monitors own work to ensure quality; Meets productivity standards; Completes work in timely manner; Strives to increase productivity; Works quickly but efficiently.
- Analytical - Synthesizes complex or diverse information; Collects and researches data; Uses intuition and experience to complement data; Designs workflows and procedures.
- Safety and Security – Observes safety and security procedures; Determines appropriate action beyond guidelines; Reports potentially unsafe conditions; Uses equipment and materials properly.
- Problem Solving – Identifies and resolves problems in a timely manner; Gathers and analyzes information skillfully; Develops alternative solutions; Works well in group problem solving situations; Uses reason even when dealing with emotional topics.
- Oral and Written Communication – Speaks clearly and persuasively in positive or negative situations; Listens and gets clarification; Responds well to questions; Demonstrates group presentation skills; Participates in meetings.
Requirements
Education
- Ph.D. degree in biochemistry, chemistry or related discipline with related experience in biology/chemistry techniques is required.
- M.S. degree in biochemistry, chemistry or a related discipline, 10+ years with related experience in biology/chemistry techniques is required.
Experience
- Hands-on experience with protein purification methodologies using various chromatography techniques.
- Proficiency in basic protein characterization techniques such as ELISA, SDS-PAGE, analytical chromatography techniques [E.g. SEC, NP/RP – HPLC, ion exchange methodologies]
- Optional Technical Skills: Experience or familiarity with protein and peptide conjugation techniques, including site-specific and non-site-specific labeling approaches (e.g., NHS-ester, maleimide, and click-chemistry-based conjugations) for use in regulated bioanalytical assays.
- Optional Technical Skills: BLI/SPR or capillary electrophoresis [CE-SDS, cIEF]; or familiarity with protein stability profiling techniques [DLS/SLS/ DSF etc].
- Strong communication and collaboration skills, with the ability to work effectively with internal teams, external partners, and key stakeholders.
- Demonstrated organizational skills with exceptional attention to detail and a high degree of precision.
- Proven ability to thrive in a fast-paced, dynamic, and highly multitasking environment while consistently delivering against objectives.
- Excellent critical-thinking, problem-solving, and analytical skills, with the capability to design, execute, and interpret complex experiments and datasets.
- Ability to work independently, manage multiple priorities, and deliver high-quality results under tight timelines and deadlines.
Physical Demands
- Ability to stand less than 1/3 of the time.
- Ability to walk less than 1/3 of the time.
- Ability to sit more than 2/3 of the time.
- Ability to talk or hear from 1/3 to 2/3 of the time.
- Ability to lift 20 lbs. less than 1/3 of the time.
Work Environment
- The work environment is in an office/laboratory environment.
- Travel up to 1-5% percent of the time.
- Frequent use of a computer is necessary.
- This position requires working independently, as well as part of a team.
- While performing the duties of this job the noise level in the work environment is usually moderately loud and has moderate temperatures.
- Personal protective equipment is required to be worn in designated lab areas: closed-toed shoes, laboratory coat, safety goggles, and gloves.
- This position requires the use of all general office equipment.
Benefits
- Paid time off (vacation, holidays, sick)
- Medical/dental/vision insurance
- 401(k) to eligible employees