Thermo Fisher Scientific
Website:
thermofisher.com
Job details:
Work Schedule
Standard (Mon-Fri)
Environmental Conditions
Office, Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.)
Role Overview
We’re not just looking for a lab executor here—this role sits at the intersection of
process development, analytics, and scale-up.
As an
Application Scientist – DSP, you will lead the design, development, and optimization of downstream purification processes for biologics in a
single-use bioprocessing environment. You’ll play a key role in enabling robust, scalable, and compliant purification workflows while collaborating across upstream, analytics, quality, and manufacturing teams.
Key Responsibilities
- Downstream Process Development & Optimization
- Design and optimize purification processes including:
- Chromatography (affinity, ion exchange, etc.)
- Filtration (TFF, depth filtration)
- Viral clearance strategies
- Perform lab-scale studies to evaluate process parameters for yield, purity, and robustness
- Implement and optimize single-use technologies in DSP workflows
- Integrate downstream processes with upstream and analytical workflows
- Pharma Analytics & Characterization
- Execute and support analytical workflows including:
- qPCR (minimum 3–4 years hands-on)
- Sanger Sequencing
- Support impurity profiling and adventitious agent testing strategies
- Interpret analytical data to guide purification and process decisions
- Collaborate with analytical teams for method development and validation
- Technology Transfer & Scale-Up
- Lead transfer of DSP processes from lab to pilot and commercial scale
- Develop and review:
- SOPs
- Batch records
- Technology transfer documents
- Troubleshoot scale-up challenges in single-use manufacturing environments
- Work closely with engineering and manufacturing teams
- Data Analysis & Documentation
- Analyze experimental data for process performance and optimization opportunities
- Ensure compliance with Good Documentation Practices (GDP)
- Prepare:
- Technical reports
- Protocols
- Client/stakeholder presentations
- Cross-Functional Collaboration
- Partner with:
- Upstream Processing
- Analytical Development
- Quality & Regulatory
- Provide technical expertise in DSP during:
- Project reviews
- Troubleshooting discussions
- Act as a subject matter expert (SME) for purification and analytics
- Continuous Improvement & Innovation
- Track advancements in:
- Downstream processing technologies
- Single-use systems
- Process Analytical Technology (PAT)
- Drive improvements in process efficiency, scalability, and cost-effectiveness
- Contribute to innovation initiatives within BDC
Qualifications
Education
- Ph.D. / M.S. / B.S./Post Graduation in:
- Chemical Engineering
- Biotechnology
- Biochemistry
- Or related field
Experience
- 8+ years in downstream process development in biopharma
- Strong expertise in:
- Chromatography
- TFF / filtration
- Viral clearance
- Hands-on lab experience with DSP equipment
- 3–4+ years hands-on experience in:
- Experience in:
- Impurity testing
- Adventitious agent testing
- Exposure to:
- Pharma analytics
- Regulated environments (cGMP)
- Customer-facing or application roles (preferred)
Skills & Competencies
- Strong process development and troubleshooting capability
- Data-driven mindset with solid analytical skills
- Effective communication and presentation skills
- Ability to manage multiple projects and timelines
- Collaborative, team-oriented approach
Preferred / Desired Attributes
- Familiarity with:
- cGMP, ICH guidelines
- Regulatory expectations for biologics
- Knowledge of:
- PAT (Process Analytical Technology)
- Automation in DSP
Click on Apply to know more.